Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.42 |
| ▸ | ITK | Q08881 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5439032 | 0.87 | KDR (0.43) | KDM4EMAPTRAB9AMEN1NPC1 | |
| SCHEMBL5480000 | 0.84 | KDR (0.42) | BTKKDM4EMAPTRAB9AMEN1 | |
| SCHEMBL5447656 | 0.81 | KDR (0.57) | BTKKDM4EMAPTRAB9AMEN1 | |
| SCHEMBL5442086 | 0.81 | BTK (0.50) | BTKKDM4EMAPTRAB9AMEN1 | |
| SCHEMBL4884350 | 0.78 | HTT (0.49) | BTKKDM4EMAPTRAB9AMEN1 | |
| SCHEMBL4884627 | 0.77 | BTK (0.52) | BTKKDM4EMAPTRAB9AMEN1 | |
| SCHEMBL4888644 | 0.77 | BTK (0.46) | BTKKDM4EMAPTRAB9AMEN1 | |
| SCHEMBL5480003 | 0.77 | KDR (0.67) | KDRAURKAPDGFRBPDGFRAFLT3 | |
| SCHEMBL14269691 | 0.72 | CHEK1 (0.54) | KDR | |
| SCHEMBL5443779 | 0.71 | CHEK1 (0.46) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | claimed |
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | IDO1, IDO2, TPH1 | BTK 2364/4885KDM4E 316/4885MAPT 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.