Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447656 | 0.84 | KDR (0.57) | KDRAURKAPDGFRBPDGFRA | |
| SCHEMBL14269691 | 0.83 | CHEK1 (0.54) | KDR | |
| SCHEMBL5079406 | 0.81 | KDR (1.00) | KDRAURKAPDGFRBPDGFRAFLT3 | |
| SCHEMBL5078761 | 0.81 | KDR (1.00) | KDRAURKAPDGFRBPDGFRAFLT3 | |
| SCHEMBL5480000 | 0.80 | KDR (0.42) | KDRAURKA | |
| SCHEMBL5078012 | 0.79 | KDR (0.98) | KDRAURKAPDGFRBPDGFRAFLT3 | |
| SCHEMBL5447652 | 0.77 | BTK (0.45) | KDRAURKAPDGFRBPDGFRAFLT3 | |
| SCHEMBL5076089 | 0.76 | KDR (0.90) | KDRAURKAPDGFRBPDGFRAHRH3 | |
| SCHEMBL16424041 | 0.74 | KDR (0.56) | KDRAURKAPDGFRBPDGFRAFLT3 | |
| SCHEMBL5443779 | 0.74 | CHEK1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | claimed |
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | IDO1, IDO2, TPH1 | KDR 2378/4885AURKA 330/4885PDGFRB 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.