Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | FDPS | P14324 | 3/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1831241 | 1.00 | SPHK1 (0.43) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| Hydrochloric Acid SCHEMBL2783886 | 1.00 | SPHK1 (0.43) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| Hydrochloric Acid SCHEMBL1840994 | 1.00 | SPHK1 (0.43) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| Hydrochloric Acid SCHEMBL9864879 | 1.00 | SPHK1 (0.43) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| Bromide SCHEMBL1840434 | 0.98 | SPHK1 (0.42) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL1838532 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL239716 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL239692 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL238534 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL15646327 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034126-B1 | COSMETIC AND DERMATOLOGICAL COMPOSITIONS FOR SHAVING THE SKIN | Maggesi, Luigi (IT) | 1984-07-04 | — | — | EP | claimed |
| US-20070118998-A1 | Methods for laundering delicate garments in a washing machine | THE PROCTER & GAMBLE COMPANY (US) | 2007-05-31 | — | — | US | disclosed |
| US-7185380-B2 | Methods for laundering delicate garments in a washing machine comprising a woven acrylic coated polyester garment container | THE PROCTER & GAMBLE COMPANY (US) | 2007-03-06 | — | — | US | disclosed |
| EP-1422334-A2 | Methods for laundering delicate garments in a washing machine | The Procter & Gamble Company (US) | 2004-05-26 | — | — | EP | disclosed |
| US-20030008799-A1 | Methods for laundering delicate garments in a washing machine | THE PROCTER & GAMBLE COMPANY (US) | 2003-01-09 | — | — | US | disclosed |
| EP-1222331-A2 | METHODS FOR LAUNDERING DELICATE GARMENTS IN A WASHING MACHINE | The Procter & Gamble Company (US) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001025525-A2 | METHODS FOR LAUNDERING DELICATE GARMENTS IN A WASHING MACHINE | THE PROCTER & GAMBLE COMPANY (US) | 2001-04-12 | — | — | WO | disclosed |
| EP-0056160-B1 | DUSTLESS DYESTUFF PREPARATIONS | BAYER AG (DE) | 1985-03-13 | — | — | EP | disclosed |
| EP-0035702-B1 | ANTIFOAMING AGENT, ITS PREPARATION AND ITS USE IN HYDROUS SYSTEMS | BAYER AG (DE) | 1985-01-23 | — | — | EP | disclosed |
| EP-0034126-B1 | COSMETIC AND DERMATOLOGICAL COMPOSITIONS FOR SHAVING THE SKIN | Maggesi, Luigi (IT) | 1984-07-04 | — | — | EP | disclosed |
| US-4402702-A | MINERAL OIL, BISAMIDE, NONIONIC SURFACTANT | BAYER AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | disclosed |
| EP-0056160-A2 | Dustless dyestuff preparations | BAYER AG (DE) | 1982-07-21 | — | — | EP | disclosed |
| EP-0035702-A2 | Antifoaming agent, its preparation and its use in hydrous systems | BAYER AG (DE) | 1981-09-16 | — | — | EP | disclosed |
| EP-0034126-A1 | Cosmetic and dermatological compositions for shaving the skin | Maggesi, Luigi (IT) | 1981-08-19 | — | — | EP | disclosed |