Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | FDPS | P14324 | 3/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5448552 | 1.00 | SPHK1 (0.43) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| Hydrochloric Acid SCHEMBL2783886 | 1.00 | SPHK1 (0.43) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| Hydrochloric Acid SCHEMBL1840994 | 1.00 | SPHK1 (0.43) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| Hydrochloric Acid SCHEMBL9864879 | 1.00 | SPHK1 (0.43) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| Bromide SCHEMBL1840434 | 0.98 | SPHK1 (0.42) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL1838532 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL239716 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL239692 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL238534 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL15646327 | 0.98 | SPHK1 (0.45) | SPHK1PSMD14PLA2G1BMMP2ATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444628-B1 | — | — | None | — | — | US | claimed |
| US-6444628-B2 | HAIR SHAMPOO FORMULATION CONTAINS A COMBINATION OF ANIONIC SURFACTANT, CATIONIC POLYMER AND A PARTICLUAR TYPE OF MONOALKYL QUATERNARY AMMONIUM COMPOUND; ENHANCED REMOVAL OF OILY MATERIALS ACCUMULATED ON THE HAIR | UNILEVER HOME & PERSONAL CARE USA, A DIVISION OF CONOPCO, INC. | 2002-09-03 | — | — | US | claimed |
| US-20020019322-A1 | Shampoo compositions | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2002-02-14 | — | — | US | claimed |
| US-6444628-B1 | — | — | None | — | — | US | disclosed |
| US-12372466-B2 | Method for determining rinse properties | CONOPCO, INC. (US) | 2025-07-29 | — | — | US | disclosed |
| EP-3642780-B1 | METHOD FOR MEASURING HAIR MOVEMENT CHARACTERISTICS | UNILEVER IP HOLDINGS B V (NL) | 2025-04-09 | — | — | EP | disclosed |
| US-12140539-B2 | Method for determining rinse properties | CONOPCO, INC. (US) | 2024-11-12 | — | — | US | disclosed |
| EP-4045893-B1 | METHOD FOR DETERMINING RINSE PROPERTIES | UNILEVER IP HOLDINGS B V (NL) | 2023-11-29 | — | — | EP | disclosed |
| US-11696884-B2 | Compositions comprising menthol compounds as smoothing agents | SYMRISE AG (DE) | 2023-07-11 | — | — | US | disclosed |
| EP-4065961-B1 | METHOD FOR DETERMINING RINSE PROPERTIES | UNILEVER IP HOLDINGS B V (NL) | 2023-03-29 | — | — | EP | disclosed |
| US-11559249-B2 | Method for measuring hair movement characteristics | CONOPCO, INC. (US) | 2023-01-24 | — | — | US | disclosed |
| WO-2002003936-A1 | SHAMPOO COMPOSITIONS | UNILEVER PLC (GB) | 2002-01-17 | — | — | WO | disclosed |
| WO-2001082891-A1 | SHAMPOO COMPOSITION CONTAINING AN MONOALKYL QUATERNARY AMMONIUM COMPOUND | UNILEVER PLC (GB) | 2001-11-08 | — | — | WO | disclosed |
| EP-0174097-B1 | HAIR SETTING METHOD USING AMINOALKYL SUBSTITUTED POLYDIORGANOSILOXANE | DOW CORNING CORPORATION (US) | 1990-06-20 | — | — | EP | disclosed |
| US-4586518-A | Hair setting method using aminoalkyl substituted polydiorganosiloxane | DOW CORNING CORPORATION (US) | 1986-05-06 | — | — | US | disclosed |
| EP-0174097-A1 | Hair setting method using aminoalkyl substituted polydiorganosiloxane | DOW CORNING CORPORATION (US) | 1986-03-12 | — | — | EP | disclosed |
| US-4521617-A | Process for preparing pure alkyl 1-hydroxy-2-naphthoates | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-06-04 | — | — | US | disclosed |
| US-4415750-A | Process for separation of 2-hydroxynapthalene-3-carboxylic acid from the reaction mixtures of alkali metal salts of 2-hydroxynaphthalene and carbon dioxide | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-11-15 | — | — | US | disclosed |
| EP-0017771-B1 | PROCESS FOR THE RECOVERY OF 2-HYDROXYNAPHTHALINE-3-CARBOXYLIC ACID FROM THE REACTION PRODUCTS OF THE ALKALI METAL SALTS OBTAINED FROM 2-HYDROXYNAPHTHALINE WITH CARBON DIOXIDE | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-09-23 | — | — | EP | disclosed |
| EP-0017771-A1 | Process for the recovery of 2-hydroxynaphthaline-3-carboxylic acid from the reaction products of the alkali metal salts obtained from 2-hydroxynaphthaline with carbon dioxide | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11696884-B2 | Compositions comprising menthol compounds as smoothing agents | SMURF1, SMURF2, S1PR2 | SPHK1 28/4885PSMD14 4310/4885PLA2G1B 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.