Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14920105 | 0.85 | MAPT (0.47) | CA1CA2CA12CA7CA9 | |
| SCHEMBL5438501 | 0.84 | CA1 (0.44) | CYP17A1CYP3A4CA1CA2ALDH1A1 | |
| SCHEMBL10751302 | 0.82 | PTPN11 (0.50) | PTPN11CYP17A1CYP3A4LCKCYP19A1 | |
| SCHEMBL263634 | 0.81 | KIF11 (0.57) | PTPN11CYP17A1CYP3A4LCKCYP19A1 | |
| SCHEMBL11744372 | 0.77 | PTPN11 (0.50) | PTPN11CYP17A1CYP3A4LCKCYP19A1 | |
| SCHEMBL29365729 | 0.76 | PTPN11 (0.68) | PTPN11LCKCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL69025 | 0.76 | PTPN11 (0.68) | PTPN11LCKCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL19554198 | 0.76 | NOTUM (0.54) | PTPN11CYP17A1CYP3A4LCKCYP19A1 | |
| SCHEMBL1367395 | 0.75 | NOTUM (0.47) | CYP3A4CA1CA2CA12CA7 | |
| SCHEMBL12601247 | 0.75 | CYP17A1 (0.50) | PTPN11CYP17A1CYP3A4LCKCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135485-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2007-06-14 | — | — | US | disclosed |
| EP-1723126-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005040157-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135485-A1 | Novel mch receptor antagonists | MCHR1, MCHR2, MC1R | PTPN11 746/4885CYP17A1 504/4885CYP3A4 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.