Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.56 |
| ▸ | ACACB | O00763 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184661 | 0.91 | ABHD6 (0.53) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL22366348 | 0.90 | ABHD6 (0.58) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL30678849 | 0.90 | ABHD6 (0.58) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL22366375 | 0.89 | ABHD6 (0.57) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL22366351 | 0.89 | ABHD6 (0.57) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL20983850 | 0.89 | ABHD6 (0.71) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL30429074 | 0.89 | ABHD6 (0.57) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL30429034 | 0.89 | ABHD6 (0.57) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL25386158 | 0.87 | ABHD6 (0.52) | ABHD6ACACBESR2MAPK1NR1H2 | |
| SCHEMBL30429430 | 0.87 | ABHD6 (0.52) | ABHD6ACACBESR2MAPK1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037846-A1 | Pyrazolidinedione derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2007-02-15 | — | — | US | disclosed |
| EP-1638540-A2 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000281-A2 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037846-A1 | Pyrazolidinedione derivatives | P2RY1, P2RY4, P2RY2 | ABHD6 2544/4885ACACB 1731/4885ESR2 2834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.