SCHEMBL5450460

SCHEMBL5450460

CCOc1ccc(/C=C/c2ccc(CC#N)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 1/20 0.59
ESR1 P03372 2/20 0.53
AHR P35869 1/20 0.53
PTGS2 P35354 1/20 0.50
TUBB4A P04350 1/20 0.49
TUBB P07437 1/20 0.49
TUBA3C P0DPH7 1/20 0.49
TUBA1B P68363 1/20 0.49
TUBA4A P68366 1/20 0.49
TUBB4B P68371 1/20 0.49
TUBB3 Q13509 1/20 0.49
TUBB2A Q13885 1/20 0.49
TUBB8 Q3ZCM7 1/20 0.49
TUBA3E Q6PEY2 1/20 0.49
TUBA1A Q71U36 1/20 0.49
TUBA1C Q9BQE3 1/20 0.49
TUBB6 Q9BUF5 1/20 0.49
TUBB2B Q9BVA1 1/20 0.49
TUBB1 Q9H4B7 1/20 0.49
MAOB P27338 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5450463 1.00 RELA (0.59) RELAESR1AHRPTGS2TUBB4A
SCHEMBL1235239 0.89 NQO1 (0.58) RELASMN1; SMN2NQO1GAA
SCHEMBL5154682 0.84 NQO1 (0.52) MAPTSMN1; SMN2NQO1NPC1RAB9A
SCHEMBL10623831 0.82 RELA (0.83) RELAESR1AHRPTGS2TUBB4A
SCHEMBL10623834 0.82 RELA (0.83) RELAESR1AHRPTGS2TUBB4A
SCHEMBL10485807 0.81 RELA (0.65) RELAESR1AHRPTGS2TUBB4A
SCHEMBL8538723 0.78 GLA (0.44) MAPTSMN1; SMN2NQO1NPC1RAB9A
SCHEMBL21457604 0.77 RELA (0.59) RELAESR1AHRPTGS2TUBB4A
SCHEMBL21457607 0.77 RELA (0.59) RELAESR1AHRPTGS2TUBB4A
SCHEMBL13247238 0.77 RELA (0.69) RELAESR1AHRPTGS2TUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070158624-A1 Time-temperature indicators NATIONAL SCIENCE FOUNDATION 2007-07-12 US disclosed