SCHEMBL8538723

SCHEMBL8538723

CCOc1ccc2cc(CC#N)ccc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.44
TSHR P16473 2/20 0.44
MEN1 O00255 1/20 0.44
NPC1 O15118 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPT P10636 1/20 0.44
RAB9A P51151 1/20 0.44
KMT2A Q03164 1/20 0.44
NQO1 P15559 1/20 0.43
TDP1 Q9NUW8 2/20 0.43
KDM4E B2RXH2 2/20 0.43
AKR1C3 P42330 1/20 0.42
AKR1C2 P52895 1/20 0.42
GAA P10253 2/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CYP1A2 P05177 1/20 0.41
CA4 P22748 1/20 0.41
CA6 P23280 1/20 0.41
CA5A P35218 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1235239 0.83 NQO1 (0.58) TSHRNQO1TDP1GAACA12
SCHEMBL1448749 0.82 PTGS1 (0.53) TSHRNPC1MAPTRAB9ANQO1
SCHEMBL6561661 0.81 KDM4E (0.59) MEN1NPC1MAPTKMT2ATDP1
SCHEMBL2294721 0.81 TP53 (0.50) TSHRALDH1A1NQO1TDP1KDM4E
SCHEMBL10017495 0.80 CYP1A2 (0.57) TSHRMEN1NPC1KMT2ANQO1
SCHEMBL11273634 0.79 CYP1A2 (0.50) NPC1MAPTRAB9ANQO1TDP1
SCHEMBL29629327 0.79 NQO1 (0.68) TSHRMEN1NPC1ALDH1A1MAPT
SCHEMBL3825385 0.79 NQO1 (0.68) TSHRMEN1NPC1ALDH1A1MAPT
SCHEMBL8875156 0.79 ALOX5 (0.65) MEN1NPC1MAPTRAB9AKMT2A
SCHEMBL5154682 0.79 NQO1 (0.52) TSHRMEN1NPC1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0807098-B1 IMPROVED PROCESS FOR REDUCTIVE HYDROLYSIS OF NITRILES DU PONT (US) 1998-09-09 EP disclosed
US-5741955-A TRANSITION METAL COMPLEX CATALYST E. I. DU PONT DE NEMOURS AND COMPANY (US) 1998-04-21 US disclosed
EP-0807098-A1 IMPROVED PROCESS FOR REDUCTIVE HYDROLYSIS OF NITRILES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-11-19 EP disclosed
WO-1996023753-A1 IMPROVED PROCESS FOR REDUCTIVE HYDROLYSIS OF NITRILES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-08-08 WO disclosed