Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HRH2 | P25021 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470158 | 0.83 | HRH4 (0.54) | ALDH1A1HPGDTMEM97SIGMAR1HRH3 | |
| SCHEMBL5465885 | 0.80 | KDM4E (0.60) | ALDH1A1TMEM97SIGMAR1HRH3DRD3 | |
| SCHEMBL5451502 | 0.80 | CCR3 (0.49) | ALDH1A1TMEM97SIGMAR1HRH3DRD3 | |
| SCHEMBL5452349 | 0.79 | HTT (0.60) | ALDH1A1HSD17B10HPGDTMEM97SIGMAR1 | |
| SCHEMBL5465825 | 0.78 | LMNA (0.58) | ALDH1A1TSHRHSD17B10RAB9AHPGD | |
| SCHEMBL5458294 | 0.78 | TMEM97 (0.45) | ALDH1A1HPGDTMEM97SIGMAR1HRH3 | |
| SCHEMBL5464881 | 0.77 | KDM4E (0.60) | ALDH1A1TMEM97SIGMAR1HRH3DRD3 | |
| SCHEMBL5468207 | 0.77 | POLB (0.56) | ALDH1A1HPGDTMEM97SIGMAR1HRH3 | |
| SCHEMBL5461750 | 0.77 | ALDH1A1 (0.60) | ALDH1A1TMEM97SIGMAR1HRH3DRD3 | |
| SCHEMBL5457085 | 0.77 | TMEM97 (0.52) | ALDH1A1HSD17B10RAB9AHPGDTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | CNR2, GRIN2C, GRIN2B | ALDH1A1 1805/4885TSHR 676/4885HSD17B10 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.