SCHEMBL5451771

SCHEMBL5451771

CC(C)Oc1cccc2c(C(=O)NCc3ccc(Cl)c(Cl)c3)cn(CCCN3[C@@H]4CC[C@H]3C[C@H](CC(=O)c3ccc(Cl)c(Cl)c3)C4)c12

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FSCN1 Q16658 4/20 0.38
CCR3 P51677 1/20 0.38
CNR1 P21554 4/20 0.38
WDR5 P61964 1/20 0.38
CNR2 P34972 6/20 0.37
PDE10A Q9Y233 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
APEX1 P27695 1/20 0.35
RORC P51449 1/20 0.35
LMNA P02545 1/20 0.35
SSTR3 P32745 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14411413 1.00 FSCN1 (0.38) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL5451774 1.00 FSCN1 (0.38) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL5454298 0.96 FSCN1 (0.39) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL5454301 0.96 FSCN1 (0.39) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL14411412 0.96 FSCN1 (0.39) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL14411410 0.96 FSCN1 (0.37) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL5448797 0.96 FSCN1 (0.37) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL5448794 0.96 FSCN1 (0.37) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL14412201 0.95 PDE10A (0.40) FSCN1CCR3CNR1WDR5CNR2
SCHEMBL14411406 0.95 PPARG (0.37) FSCN1CCR3CNR1WDR5CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070213359-A1 BICYCLIC-NITROGEN COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF ACADIA PHARMACEUTICALS INC. (US) 2007-09-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070213359-A1 BICYCLIC-NITROGEN COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF GIPR, GHSR, GHRHR FSCN1 4090/4885CCR3 1400/4885CNR1 65/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.