SCHEMBL5452586

SCHEMBL5452586

O=[N+]([O-])c1ccccc1NC(=S)Nc1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.65
L3MBTL1 Q9Y468 3/20 0.65
NPC1 O15118 2/20 0.65
RAB9A P51151 2/20 0.65
ALDH1A1 P00352 9/20 0.60
GAA P10253 3/20 0.60
POLB P06746 1/20 0.60
MAPK1 P28482 1/20 0.60
CASP7 P55210 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
HPGD P15428 1/20 0.59
MEN1 O00255 4/20 0.58
KMT2A Q03164 4/20 0.58
LMNA P02545 2/20 0.56
CYP3A4 P08684 1/20 0.55
TAS2R38 P59533 1/20 0.55
HSD17B10 Q99714 1/20 0.55
CXCR1 P25024 1/20 0.55
CXCR2 P25025 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1314971 0.88 MAPT (0.57) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL6815123 0.87 GAA (0.60) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL15347550 0.82 MAPT (0.62) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL4388940 0.82 CXCR2 (0.78) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL6717195 0.80 MAPT (0.54) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL4251730 0.79 MAPT (1.00) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL11373029 0.78 NPC1 (0.70) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL8458957 0.78 MEN1 (0.62) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL29838526 0.78 MEN1 (0.62) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL1883671 0.78 MEN1 (0.62) MAPTL3MBTL1NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12408914-B2 Systems and methods for customizing mechanical strength in stimuli-responsive bioabsorbable materials CILAG GMBH INTERNATIONAL (CH) 2025-09-09 US disclosed
US-20240423617-A1 SYSTEMS AND METHODS FOR CUSTOMIZING MECHANICAL STRENGTH IN STIMULI-RESPONSIVE BIOABSORBABLE MATERIALS CILAG GMBH INTERNATIONAL (CH) 2024-12-26 US disclosed
US-20240423620-A1 COMPRESSIBLE SURGICAL ADJUNCTS, CARTRIDGES, AND CARTRIDGE ASSEMBLIES AND METHODS OF MAKING SURGICAL ADJUNCTS CILAG GMBH INTERNATIONAL (CH) 2024-12-26 US disclosed
US-20070040151-A1 Two-component initiator system (amine-free) with very good storage stability and particular suitability for acid systems HERAEUS KULZER GMBH (DE) 2007-02-22 US disclosed