Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | RRM1 | P23921 | 1/20 | 0.49 |
| ▸ | RRM2 | P31350 | 1/20 | 0.49 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5452586 | 0.88 | MAPT (0.65) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL6815123 | 0.84 | GAA (0.60) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1311622 | 0.84 | CXCR1 (0.62) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL15347550 | 0.80 | MAPT (0.62) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7171202 | 0.79 | MAPK1 (0.74) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL1314972 | 0.79 | ALDH1A1 (0.73) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL29838526 | 0.77 | MEN1 (0.62) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1883671 | 0.77 | MEN1 (0.62) | MAPTMEN1KMT2ARAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL8764180 | 0.75 | MEN1 (0.60) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1311643 | 0.75 | CA12 (0.55) | MAPTMEN1KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385831-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | The UAB Research Foundation (US) | 2011-11-16 | — | — | EP | claimed |
| US-20110254866-A1 | INFORMATION PROCESSING APPARATUS, METHOD AND PROGRAM THEREFORE | SONY CORPORATION (JP) | 2011-10-20 | — | — | US | claimed |
| WO-2010123591-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | THE UAB RESEARCH FOUNDATION (US) | 2010-10-28 | — | — | WO | claimed |
| EP-2385831-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | The UAB Research Foundation (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110275635-A1 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | THE UAB RESEARCH FOUNDATION (US) | 2011-11-10 | — | — | US | disclosed |
| US-20110254866-A1 | INFORMATION PROCESSING APPARATUS, METHOD AND PROGRAM THEREFORE | SONY CORPORATION (JP) | 2011-10-20 | — | — | US | disclosed |
| WO-2010123591-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | THE UAB RESEARCH FOUNDATION (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275635-A1 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | NAMPT, NAPRT, NNT | MAPT 833/4885MEN1 889/4885KMT2A 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.