Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.61 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.61 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.61 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.61 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.61 |
| ▸ | THRB | P10828 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25301058 | 0.88 | TDP1 (0.80) | TDP1MAPK1THRBMAPTMEN1 | |
| Zinc Ion SCHEMBL29366028 | 0.85 | TDP1 (0.75) | TDP1MAPK1THRBMAPTMEN1 | |
| Bromide SCHEMBL25280 | 0.80 | TDP1 (0.70) | TDP1MAPK1THRBMAPTMEN1 | |
| SCHEMBL12671027 | 0.79 | TDP1 (0.69) | TDP1MAPK1THRBMAPTMEN1 | |
| SCHEMBL4656587 | 0.79 | TDP1 (0.57) | TDP1MAPK1THRBMAPTMEN1 | |
| Zinc Chloride SCHEMBL29577877 | 0.77 | TDP1 (0.65) | TDP1MAPK1THRBMAPTMEN1 | |
| Hexamethyl Pararosaniline SCHEMBL9171 | 0.77 | TDP1 (1.00) | TDP1MAPK1THRBMAPTMEN1 | |
| Zinc Chloride SCHEMBL29837408 | 0.76 | TDP1 (0.64) | TDP1MAPK1THRBMAPTMEN1 | |
| Hexamethyl Pararosaniline SCHEMBL94116 | 0.75 | TDP1 (0.96) | TDP1MAPK1THRBMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL29350825 | 0.74 | MEN1 (0.51) | TDP1MAPK1THRBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070020560-A1 | Limited play optical discs | CONSUMABLE MEDIA LLC | 2007-01-25 | — | — | US | disclosed |
| WO-2006130496-A1 | LIMITED PLAY OPTICAL DISCS | CONSUMABLE MEDIA LLC (US) | 2006-12-07 | — | — | WO | disclosed |