Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 3/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655741 | 0.84 | CACNA1G (0.46) | CACNA1GCACNA1BCACNA1CNR1H2SLC6A4 | |
| SCHEMBL31468983 | 0.83 | HTR2C (0.38) | CACNA1GCACNA1BCACNA1CNR1H2SLC6A4 | |
| SCHEMBL8169426 | 0.83 | RIPK1 (0.46) | CACNA1GCACNA1BCACNA1CSLC6A4HTR2C | |
| SCHEMBL5423901 | 0.82 | NR1H2 (0.48) | NR1H2GAAGLAPOLBTSHR | |
| SCHEMBL13622928 | 0.82 | HTR2C (0.37) | CACNA1GCACNA1BCACNA1CNR1H2SLC6A4 | |
| SCHEMBL4656684 | 0.81 | NOTUM (0.47) | CACNA1GCACNA1BCACNA1CNR1H2GAA | |
| SCHEMBL17705199 | 0.81 | CACNA1G (0.36) | CACNA1GCACNA1BCACNA1CNR1H2SLC6A4 | |
| SCHEMBL8162665 | 0.81 | SLC6A4 (0.40) | CACNA1GCACNA1BCACNA1CSLC6A4HTR2C | |
| SCHEMBL20214469 | 0.81 | CACNA1G (0.43) | CACNA1GCACNA1BCACNA1CGAAPOLB | |
| SCHEMBL18186254 | 0.80 | HTR2C (0.38) | CACNA1GCACNA1BCACNA1CNR1H2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |