Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 4/20 | 0.44 |
| ▸ | LGALS8 | O00214 | 2/20 | 0.43 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5444098 | 0.91 | KDM4E (0.46) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL5807345 | 0.88 | RAF1 (0.42) | ALDH1A1HPGDLGALS8LGALS3RAF1 | |
| SCHEMBL31287683 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL14627466 | 0.78 | RAF1 (0.38) | RAF1BRAFSMN1; SMN2KDRTEK | |
| SCHEMBL8869770 | 0.74 | KDM4E (0.62) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL5447398 | 0.74 | PTGES (0.40) | RAF1BRAFKDRTEK | |
| SCHEMBL31287769 | 0.73 | KDM4E (0.69) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL5450095 | 0.73 | KDR (0.44) | LMNAHTTL3MBTL1RAF1BRAF | |
| SCHEMBL31287713 | 0.72 | KDM4E (0.70) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL31287767 | 0.72 | KDM4E (0.70) | KDM4EALDH1A1HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021456-A1 | Aminobenzimidazole derivatives | MERCK PATENT GMBH (DE) | 2007-01-25 | — | — | US | claimed |
| US-20070021456-A1 | Aminobenzimidazole derivatives | MERCK PATENT GMBH (DE) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021456-A1 | Aminobenzimidazole derivatives | TIE1, KDR, FLT1 | KDM4E 129/4885ALDH1A1 1159/4885HPGD 3924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.