Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 10/20 | 0.40 |
| ▸ | TEK | Q02763 | 8/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.35 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453152 | 0.88 | KDM4E (0.46) | RAF1BRAFKDRTEKLGALS8 | |
| SCHEMBL5444098 | 0.79 | KDM4E (0.46) | RAF1BRAFKDRTEKLGALS8 | |
| SCHEMBL14627466 | 0.77 | RAF1 (0.38) | RAF1BRAFKDRTEK | |
| SCHEMBL5796359 | 0.76 | PTGES (0.40) | RAF1BRAFKDRTEK | |
| SCHEMBL5450095 | 0.72 | KDR (0.44) | RAF1BRAFKDRTEK | |
| SCHEMBL5796233 | 0.71 | BRAF (0.36) | RAF1BRAFKDRTEK | |
| SCHEMBL14521447 | 0.71 | POLB (0.41) | KDRALDH1A1 | |
| SCHEMBL5456884 | 0.71 | NPC1 (0.46) | RAF1BRAFKDRTEKALDH1A1 | |
| SCHEMBL5447398 | 0.70 | PTGES (0.40) | RAF1BRAFKDRTEK | |
| SCHEMBL5795361 | 0.70 | RIPK1 (0.41) | RAF1BRAFKDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656377-A1 | AMINOBENZIMIDAZOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-05-17 | — | — | EP | claimed |
| WO-2005019216-A1 | AMINOBENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-03-03 | — | — | WO | claimed |