Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5467702 | 0.86 | ALDH1A1 (0.38) | HTR2CHTR2BALDH1A1LMNAKDM4E | |
| SCHEMBL5458409 | 0.74 | AR (0.39) | NPC1RAB9AHTTSMN1; SMN2MAPT | |
| SCHEMBL1862187 | 0.70 | MAPT (0.36) | NPC1PKMSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL23886029 | 0.69 | NPC1 (0.41) | NPC1PARP1RAB9APKMALDH1A1 | |
| SCHEMBL5466965 | 0.68 | AR (0.39) | HTTHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL25171202 | 0.67 | NPC1 (0.39) | NPC1RAB9ANPSR1PKMMITF | |
| SCHEMBL1862188 | 0.67 | IDO1 (0.38) | NPC1RAB9AMAPTIDO1LOXL2 | |
| SCHEMBL30019940 | 0.67 | TP53 (0.38) | HTTSMN1; SMN2MAPTTP53HTR2C | |
| SCHEMBL23885998 | 0.67 | TP53 (0.38) | HTTSMN1; SMN2MAPTTP53HTR2C | |
| SCHEMBL25128096 | 0.66 | ABL1 (0.40) | NPC1PARP1RAB9ANPSR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093531-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG | 2007-04-26 | — | — | US | disclosed |
| US-7166637-B2 | Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG (DE) | 2007-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093531-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | PDE4B, PDE4A, PDE4D | NPC1 3662/4885PARP1 2104/4885RAB9A 2277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.