Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453767 | 0.86 | NPC1 (0.34) | ALDH1A1LMNAMEN1KMT2AHTR2C | |
| SCHEMBL5469027 | 0.72 | AR (0.41) | ALDH1A1LMNAMEN1KMT2AHTR2C | |
| SCHEMBL15140275 | 0.71 | LMNA (0.36) | ALDH1A1LMNAHSP90AB1KMT2AIDO1 | |
| SCHEMBL17663880 | 0.70 | HSP90AB1 (0.40) | ALDH1A1LMNAHSP90AB1MEN1KMT2A | |
| SCHEMBL5466965 | 0.70 | AR (0.39) | ALDH1A1LMNAHTR2CHTR2BTAAR1 | |
| SCHEMBL3540407 | 0.68 | MEN1 (0.46) | ALDH1A1MEN1KMT2AIDO1TAAR1 | |
| SCHEMBL17663941 | 0.68 | MEN1 (0.39) | ALDH1A1LMNAHSP90AB1MEN1KMT2A | |
| SCHEMBL5460708 | 0.67 | KDM4E (0.31) | KDM4E | |
| SCHEMBL17664078 | 0.67 | MEN1 (0.39) | ALDH1A1LMNAHSP90AB1MEN1KMT2A | |
| SCHEMBL1106684 | 0.66 | IDO1 (0.58) | ALDH1A1LMNAHSP90AB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093531-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG | 2007-04-26 | — | — | US | disclosed |
| US-7166637-B2 | Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG (DE) | 2007-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093531-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | PDE4B, PDE4A, PDE4D | ALDH1A1 1815/4885LMNA 2290/4885CRHBP 3174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.