Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991108 | 0.84 | KCNA3 (0.57) | KCNA3HTTCYP3A4LMNACYP1A2 | |
| SCHEMBL94801 | 0.82 | KCNA3 (0.61) | KCNA3HTTCYP3A4LMNACYP1A2 | |
| SCHEMBL4371294 | 0.80 | HPGD (0.56) | KCNA3SETDB1CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL96699 | 0.79 | KCNA3 (0.67) | KCNA3HTTCYP3A4LMNACYP1A2 | |
| SCHEMBL14251166 | 0.79 | KCNA3 (0.61) | KCNA3HTTCYP3A4LMNACYP1A2 | |
| SCHEMBL11144866 | 0.79 | KCNA3 (0.61) | KCNA3HTTCYP3A4LMNACYP1A2 | |
| Water SCHEMBL21694712 | 0.78 | HPGD (0.55) | KCNA3SETDB1CYP3A4CYP1A2CYP2C19 | |
| Ethylene SCHEMBL3362752 | 0.78 | HPGD (0.55) | KCNA3SETDB1CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL96203 | 0.78 | KCNA3 (0.69) | KCNA3HTTCYP3A4LMNACYP1A2 | |
| SCHEMBL96408 | 0.77 | KCNA3 (0.72) | KCNA3HTTCYP3A4LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| CN-1608061-A | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2005-04-20 | — | — | CN | disclosed |
| EP-1451172-A1 | THERAPEUTIC ISOQUINOLINE COMPOUNDS | AstraZeneca AB (SE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003037887-A1 | THERAPEUTIC ISOQUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | HTR1B, HTR1D, HTR1A | KCNA3 1248/4885HTT 322/4885SETDB1 3469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.