Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT known ✓ | P43490 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14447605 | 1.00 | CYP17A1 (0.43) | CYP17A1NAMPTMAP4K4KDRBRAF | |
| Hydrochloric Acid SCHEMBL5453188 | 0.87 | CYP17A1 (0.41) | CYP17A1NAMPTKDRBRAFMAPK14 | |
| SCHEMBL14447628 | 0.87 | CYP17A1 (0.41) | CYP17A1NAMPTKDRBRAFMAPK14 | |
| SCHEMBL5444453 | 0.84 | KDR (0.46) | CYP17A1NAMPTMAP4K4KDRBRAF | |
| SCHEMBL14447606 | 0.81 | P2RX3 (0.43) | CYP17A1NAMPTMAP4K4KDRBRAF | |
| SCHEMBL14447603 | 0.80 | SIRT2 (0.42) | CYP17A1NAMPTMAP4K4KDRBRAF | |
| SCHEMBL14447604 | 0.77 | CYP17A1 (0.40) | CYP17A1NAMPTMAP4K4KDRBRAF | |
| SCHEMBL14447591 | 0.77 | MAP4K4 (0.46) | CYP17A1MAP4K4KDRBRAFMAPK14 | |
| SCHEMBL29131710 | 0.76 | HPGD (0.59) | CYP17A1NAMPTMAP4K4PSMB8 | |
| SCHEMBL5336104 | 0.76 | CYP17A1 (0.41) | CYP17A1NAMPTMAP4K4KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | BRAF, ARAF, RAF1 | NAMPT 1911/4885CYP17A1 4528/4885MAP4K4 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.