Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 17/20 | 0.82 |
| ▸ | TMEM97 | Q5BJF2 | 15/20 | 0.82 |
| ▸ | HTR1A | P08908 | 3/20 | 0.82 |
| ▸ | HRH2 | P25021 | 3/20 | 0.82 |
| ▸ | HRH1 | P35367 | 3/20 | 0.82 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.82 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.82 |
| ▸ | HTR2A | P28223 | 2/20 | 0.82 |
| ▸ | HTR2C | P28335 | 2/20 | 0.82 |
| ▸ | HTR2B | P41595 | 2/20 | 0.82 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.82 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.82 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.82 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.82 |
| ▸ | DRD3 | P35462 | 1/20 | 0.82 |
| ▸ | HTR5A | P47898 | 1/20 | 0.82 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.77 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456834 | 0.98 | TMEM97 (0.82) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL19521514 | 0.90 | TMEM97 (1.00) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL19521491 | 0.89 | TMEM97 (1.00) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL19521544 | 0.88 | TMEM97 (1.00) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL19521496 | 0.87 | TMEM97 (1.00) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL19521482 | 0.87 | SIGMAR1 (1.00) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL5468405 | 0.85 | KDM4E (0.67) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL5458981 | 0.82 | TMEM97 (0.66) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL13636153 | 0.81 | SIGMAR1 (0.65) | SIGMAR1TMEM97HTR1AHRH2HRH1 | |
| SCHEMBL5465885 | 0.81 | KDM4E (0.60) | SIGMAR1TMEM97HTR1AHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | claimed |
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| EP-1730114-A1 | BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005087746-A1 | BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | CNR2, GRIN2C, GRIN2B | SIGMAR1 129/4885TMEM97 486/4885HTR1A 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.