Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.47 |
| ▸ | IGF1R | P08069 | 7/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT5A | P42229 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799483 | 0.89 | NTRK1 (0.57) | NTRK1IGF1RFGFR1AURKAPLK4 | |
| SCHEMBL3338201 | 0.89 | NTRK1 (0.59) | NTRK1IGF1RFGFR1AURKAPLK4 | |
| SCHEMBL3338360 | 0.78 | IGF1R (0.64) | NTRK1IGF1RFGFR1JAK2JAK3 | |
| SCHEMBL3335945 | 0.78 | NTRK1 (0.72) | NTRK1IGF1RFGFR1AURKAPLK4 | |
| SCHEMBL29794658 | 0.73 | IGF1R (0.80) | NTRK1IGF1R | |
| SCHEMBL4070291 | 0.73 | IGF1R (0.80) | NTRK1IGF1R | |
| SCHEMBL3338511 | 0.73 | NTRK1 (0.57) | NTRK1IGF1RFGFR1AURKAPLK4 | |
| SCHEMBL4034569 | 0.70 | IGF1R (0.66) | NTRK1IGF1RFGFR1AURKAPLK4 | |
| SCHEMBL4038016 | 0.68 | IGF1R (0.79) | NTRK1IGF1RFGFR1AURKAPLK4 | |
| SCHEMBL4031791 | 0.67 | IGF1R (0.79) | NTRK1IGF1RFGFR1AURKAPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511589-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1686999-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | AstraZeneca AB (SE) | 2006-08-09 | — | — | EP | claimed |
| WO-2005049033-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | WO | claimed |