Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.34 |
| ▸ | TET3 | O43151 | 1/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vinyl Chloride SCHEMBL5447669 | 0.91 | — | — | |
| Malic Acid SCHEMBL8777956 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2TET2TET3TET1 | |
| Malic Acid SCHEMBL28842768 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2TET2TET3TET1 | |
| Malic Acid SCHEMBL6419336 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2TET2TET3TET1 | |
| Vinyl Chloride SCHEMBL4029780 | 0.78 | CYP2C19 (0.36) | TET2TET3TET1 | |
| Methacrylic Acid SCHEMBL11132733 | 0.73 | CYP2C19 (0.35) | TET2TET3TET1 | |
| SCHEMBL902141 | 0.72 | CYP2C19 (0.39) | TET2TET3TET1 | |
| SCHEMBL31199 | 0.72 | CYP2C19 (0.39) | TET2TET3TET1 | |
| Methacrylic Acid SCHEMBL8143125 | 0.69 | HSD17B10 (0.32) | — | |
| Vinyl Chloride SCHEMBL28801339 | 0.69 | HSD17B10 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7208237-B2 | Magnetic recording medium | TDK CORPORATION (JP) | 2007-04-24 | — | — | US | disclosed |
| US-7157163-B2 | Magnetic recording medium | TDK CORPORATION (JP) | 2007-01-02 | — | — | US | disclosed |
| US-7011900-B2 | Magnetic recording medium | TDK CORPORATION (JP) | 2006-03-14 | — | — | US | disclosed |
| US-20040209121-A1 | Magnetic recording medium | TDK CORPORATION (JP) | 2004-10-21 | — | — | US | disclosed |
| US-20040207955-A1 | Magnetic recording medium | TDK CORPORATION (JP) | 2004-10-21 | — | — | US | disclosed |
| US-20040197605-A1 | Magnetic recording medium | TDK CORPORATION (JP) | 2004-10-07 | — | — | US | disclosed |