Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.36 |
| ▸ | TET3 | O43151 | 2/20 | 0.36 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL28842768 | 0.95 | SMN1; SMN2 (0.46) | SMN1; SMN2TET2TET3TET1 | |
| Malic Acid SCHEMBL6419336 | 0.95 | SMN1; SMN2 (0.56) | SMN1; SMN2TET2TET3TET1ALOX15 | |
| Malic Acid SCHEMBL5456657 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2TET2TET3TET1 | |
| SCHEMBL27550458 | 0.79 | GPR84 (0.34) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Malic Acid SCHEMBL3809552 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2TET2TET3TET1KMO | |
| Acetic Acid SCHEMBL28181036 | 0.78 | FFAR3 (0.35) | LMNA | |
| Bicarbonate SCHEMBL14972727 | 0.78 | ALDH1A1 (0.35) | LMNA | |
| Vinyl Chloride SCHEMBL7758502 | 0.78 | ALDH1A1 (0.38) | — | |
| Vinyl Chloride SCHEMBL15910987 | 0.78 | ALDH1A1 (0.38) | — | |
| Vinyl Chloride SCHEMBL8398856 | 0.78 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668602-A | Instant film unit | FUJI PHOTO FILM CO., LTD. (JP) | 1987-05-26 | — | — | US | claimed |
| EP-0312074-B1 | Method of improving a magnetic recording medium and magnetic recording medium | KONISHIROKU PHOTO IND (JP) | 1997-12-17 | — | — | EP | disclosed |
| US-5055349-A | Durability, high density | KONICA CORPORATION (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0312074-A2 | Method of improving a magnetic recording medium and magnetic recording medium | KONICA CORPORATION (JP) | 1989-04-19 | — | — | EP | disclosed |
| US-4668602-A | Instant film unit | FUJI PHOTO FILM CO., LTD. (JP) | 1987-05-26 | — | — | US | disclosed |