Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28395310 | 0.95 | POLB (0.51) | POLBP2RX7CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL27503313 | 0.87 | CYP17A1 (0.60) | POLBCYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL28643239 | 0.85 | FYN (0.52) | POLBP2RX7CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL8137336 | 0.84 | POLB (0.64) | POLBCYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL1422886 | 0.83 | MAPK1 (0.70) | POLBP2RX7MAPK1HTTCYP3A4 | |
| SCHEMBL28308744 | 0.81 | KDM4E (0.51) | FYNNPC1ALDH1A1HSD17B10ADORA3 | |
| SCHEMBL7368774 | 0.81 | P2RX7 (0.50) | POLBP2RX7CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL23515364 | 0.81 | CYP11B1 (0.50) | POLBP2RX7CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL12381484 | 0.81 | CYP11B1 (0.74) | POLBCYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL29625759 | 0.81 | CYP11B1 (0.50) | POLBP2RX7CYP17A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39663-E1 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes | APPLERA CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1196640-B1 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | APPLERA CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1196640-A2 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | Applera Corporation (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001057264-A2 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | APPLERA CORPORATION (US) | 2001-08-09 | — | — | WO | disclosed |
| US-6221604-B1 | CONJUGATED TO SUBSTRATES SUCH AS NUCLEOSIDES OR NUCLEOTIDES AND USED AS DETECTION LABELS IN MOLECULAR BIOLOGY EXPERIMENTS; ENERGY TRANSFER DYE | PE CORPORATION | 2001-04-24 | — | — | US | disclosed |