Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5465100 | 0.90 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1NPC1RAB9ATRAP1 | |
| SCHEMBL14582323 | 0.86 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TRAP1TSHRLMNA | |
| SCHEMBL14582311 | 0.85 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1RAB9ATRAP1TSHR | |
| SCHEMBL14582312 | 0.84 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1TRAP1TSHRHPGD | |
| SCHEMBL1780605 | 0.84 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1TRAP1TSHRLMNA | |
| SCHEMBL14582359 | 0.83 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1TRAP1HPGD | |
| SCHEMBL5466848 | 0.82 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TRAP1TSHRHPGD | |
| SCHEMBL14582445 | 0.82 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TRAP1TSHRHPGD | |
| SCHEMBL14582357 | 0.82 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TRAP1 | |
| SCHEMBL5463158 | 0.81 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | TK1, TK2, SLC1A5 | HSP90AA1 3373/4885HSP90AB1 3036/4885NPC1 865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.