Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5472446 | 0.87 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ADRA2AADRA1ABRD4 | |
| SCHEMBL14582311 | 0.85 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL14582312 | 0.84 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1780605 | 0.84 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1BRD4ALDH1A1HTT | |
| SCHEMBL14582445 | 0.82 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1BRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL14582357 | 0.82 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1IKBKBBRD4ALDH1A1 | |
| SCHEMBL5466848 | 0.82 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1BRD4CREBBPALDH1A1 | |
| SCHEMBL5465100 | 0.82 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ADRA2AADRA1ABRD4 | |
| SCHEMBL14582323 | 0.82 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ALDH1A1LMNAGAA | |
| SCHEMBL5457927 | 0.81 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ADRA2AADRA1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | TK1, TK2, SLC1A5 | HSP90AA1 3373/4885HSP90AB1 3036/4885ADRA2A 827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.