Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | F13A1 | P00488 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 5/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.33 |
| ▸ | PPARG | P37231 | 6/20 | 0.33 |
| ▸ | PPARD | Q03181 | 6/20 | 0.33 |
| ▸ | PPARA | Q07869 | 6/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | FABP4 | P15090 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14340364 | 0.99 | TDP1 (0.37) | TDP1LMNAMEN1KMT2AMAPT | |
| SCHEMBL28562582 | 0.87 | KMT2A (0.55) | TDP1LMNAMEN1KMT2AMAPT | |
| SCHEMBL1105636 | 0.87 | KMT2A (0.55) | TDP1LMNAMEN1KMT2AMAPT | |
| SCHEMBL2614442 | 0.85 | KMT2A (0.56) | TDP1LMNAMEN1KMT2AMAPT | |
| Bromide SCHEMBL2910111 | 0.85 | HDAC3 (0.39) | TDP1LMNAMEN1KMT2AMAPT | |
| SCHEMBL13173050 | 0.84 | LMNA (0.40) | TDP1LMNAMEN1KMT2AMAPT | |
| SCHEMBL18715387 | 0.84 | MAPT (0.40) | TDP1LMNAMEN1KMT2AMAPT | |
| SCHEMBL3418484 | 0.84 | LMNA (0.40) | TDP1LMNAMEN1KMT2AMAPT | |
| SCHEMBL19063420 | 0.84 | MEN1 (0.40) | TDP1LMNAMEN1KMT2AMAPT | |
| SCHEMBL16500586 | 0.84 | KMT2A (0.40) | TDP1LMNAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070281363-A1 | Reporter molecules based on squaric, croconic, and/or rhodizonic acid; photoluminescence | Terpetschnig, Ewald (US) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281363-A1 | Reporter molecules based on squaric, croconic, and/or rhodizonic acid; photoluminescence | SPR, SRRT, SQLE | TDP1 4192/4885LMNA 1873/4885MEN1 2672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.