Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GABRP | O00591 | 5/20 | 0.52 |
| ▸ | GABRD | O14764 | 5/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.52 |
| ▸ | GABRE | P78334 | 5/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.52 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.52 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.52 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19329749 | 0.86 | PTPN1 (0.52) | POLBPTPN1MAPTLMNAGABRP | |
| SCHEMBL24683233 | 0.82 | GABRP (0.58) | PTPN1MAPTLMNAGABRPGABRD | |
| SCHEMBL19353146 | 0.81 | PTPN1 (0.57) | PTPN1MAPTGABRPGABRDGABRA1 | |
| SCHEMBL5446002 | 0.80 | PTPN1 (0.54) | POLBPTPN1MAPTLMNAGABRP | |
| SCHEMBL5450926 | 0.80 | POLB (0.64) | POLBPTPN1MAPTLMNAALDH1A1 | |
| SCHEMBL5455249 | 0.80 | KCNH2 (0.50) | PTPN1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL5455182 | 0.79 | MAPT (0.81) | POLBMAPTLMNAALDH1A1KMT2A | |
| SCHEMBL5453513 | 0.79 | FLT3 (0.62) | POLBPTPN1MAPTALDH1A1KMT2A | |
| SCHEMBL5458434 | 0.78 | PTPN1 (0.55) | POLBPTPN1MAPTALDH1A1KMT2A | |
| SCHEMBL4086551 | 0.78 | KMT2A (0.55) | POLBPTPN1MAPTLMNAGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275962-A1 | Heterobicyclic Compounds as Pharmaceutically Active Agents | GPC BIOTECH AG (DE) | 2007-11-29 | — | — | US | disclosed |
| US-20070275962-A1 | Heterobicyclic Compounds as Pharmaceutically Active Agents | GPC BIOTECH AG (DE) | 2007-11-29 | — | — | US | disclosed |
| EP-1670804-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC Biotech AG (DE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005023818-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC BIOTECH AG (DE) | 2005-03-17 | — | — | WO | disclosed |
| WO-2005023818-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC BIOTECH AG (DE) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275962-A1 | Heterobicyclic Compounds as Pharmaceutically Active Agents | TBCA, PARK7, NFATC1 | POLB 404/4885PTPN1 2192/4885MAPT 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.