Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10965684 | 0.72 | SMN1; SMN2 (0.40) | — | |
| SCHEMBL7144536 | 0.70 | KDM4E (0.30) | HTT | |
| SCHEMBL7194482 | 0.69 | HIF1A (0.30) | — | |
| SCHEMBL532653 | 0.67 | HIF1A (0.49) | HTT | |
| SCHEMBL29416453 | 0.66 | DYRK1A (0.48) | HTTPTK2 | |
| SCHEMBL5384173 | 0.66 | DYRK1A (0.48) | HTTPTK2 | |
| SCHEMBL397509 | 0.66 | PI4KA (0.50) | HTTPTK2 | |
| SCHEMBL7144530 | 0.62 | — | — | |
| SCHEMBL12462960 | 0.62 | HTT (0.38) | HTTPTK2 | |
| SCHEMBL21347892 | 0.62 | HTT (0.38) | HTTPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076515-B1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | LILLY CO ELI (US) | 2013-07-17 | — | — | EP | disclosed |
| US-8110580-B2 | Thiophene pyrazolopyrimidine compounds | ELI LILLY AND COMPANY (US) | 2012-02-07 | — | — | US | disclosed |
| US-8030304-B2 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists | ELI LILLY AND COMPANY (US) | 2011-10-04 | — | — | US | disclosed |
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |
| US-20100222339-A1 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists | ELI LILLY AND COMPANY | 2010-09-02 | — | — | US | disclosed |
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CHEN ZHAOGEN | 2010-01-28 | — | — | US | disclosed |
| EP-2094709-A1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2009-09-02 | — | — | EP | disclosed |
| EP-2076515-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008036541-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008036579-A1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222339-A1 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists | CRHR1, CRH, CRHR2 | HTT 1332/4885PTK2 2359/4885 |
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CRH, CRHR1, CRHR2 | HTT 1050/4885PTK2 2828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.