Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPEPPS | P55786 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.47 |
| ▸ | KDM5A | P29375 | 6/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5476046 | 0.84 | GNRHR (0.46) | NPEPPSKDM4EGAATP53NPC1 | |
| SCHEMBL5467370 | 0.82 | ALDH1A1 (0.51) | NPEPPSKDM4EGAANPC1SMN1; SMN2 | |
| SCHEMBL16857004 | 0.81 | KDM4E (0.63) | NPEPPSAURKAKDM4EGAATP53 | |
| SCHEMBL5474270 | 0.80 | CRBN (0.49) | KDM4CKDM5AKDM5BSMN1; SMN2ALDH1A1 | |
| SCHEMBL6975916 | 0.78 | NPEPPS (0.54) | NPEPPSKDM4EGAATP53SMN1; SMN2 | |
| SCHEMBL5461862 | 0.78 | GAA (0.67) | NPEPPSAURKAKDM4EGAATP53 | |
| SCHEMBL5474006 | 0.75 | KDM4E (0.52) | NPEPPSAURKAKDM4EGAATP53 | |
| SCHEMBL5470611 | 0.75 | KDM4E (0.60) | NPEPPSAURKAKDM4EGAATP53 | |
| SCHEMBL5469140 | 0.74 | NPEPPS (0.50) | NPEPPSAURKAKDM4EGAATP53 | |
| SCHEMBL5472974 | 0.73 | NPEPPS (0.49) | NPEPPSAURKAKDM4EGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | US | disclosed |
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | US | disclosed |
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | US | disclosed |
| EP-1657238-A1 | FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | NR5A1, GNRHR, RXFP3 | NPEPPS 2487/4885KDM4C 3789/4885KDM5A 2613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.