Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464658 | 1.00 | ALDH1A1 (0.43) | ALDH1A1KMT2AATMITGB3ITGAV | |
| SCHEMBL5455791 | 0.81 | HPGD (0.44) | ALDH1A1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL5459727 | 0.81 | HPGD (0.44) | ALDH1A1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL5457165 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL5459715 | 0.80 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL2662739 | 0.74 | HCRTR1 (0.42) | KMT2AMEN1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL5463734 | 0.69 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL2643558 | 0.67 | MEN1 (0.53) | ALDH1A1KMT2AMEN1AKR1B1KDM4E | |
| SCHEMBL10551987 | 0.66 | FFAR1 (0.46) | ALDH1A1KMT2ASMN1; SMN2KDM4EHPGD | |
| SCHEMBL2662538 | 0.65 | HTT (0.38) | KMT2AMEN1AKR1B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070117808-A1 | Substituted Cycloalkylpyrrolones As Allosteric Modulators Of Glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117808-A1 | Substituted Cycloalkylpyrrolones As Allosteric Modulators Of Glucokinase | GCKR, GCK, GALK1 | ALDH1A1 2410/4885KMT2A 3643/4885ATM 891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.