Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 9/20 | 0.44 |
| ▸ | FLT1 | P17948 | 8/20 | 0.42 |
| ▸ | FLT4 | P35916 | 8/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.41 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5465359 | 0.86 | VCP (0.65) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5469307 | 0.82 | VCP (0.53) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5477719 | 0.79 | VCP (0.46) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5472990 | 0.78 | VCP (0.46) | VCP | |
| SCHEMBL16349175 | 0.77 | KDR (0.45) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5475253 | 0.76 | VCP (0.50) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5235804 | 0.76 | VCP (0.49) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5472953 | 0.74 | VCP (0.48) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL16348971 | 0.74 | VCP (0.48) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5481749 | 0.74 | VCP (0.46) | VCPKDRFLT1FLT4IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142437-A1 | CHEMICAL COMPOUNDS | BROWN MATTHEW L | 2007-06-21 | — | — | US | claimed |
| US-20050288515-A1 | Chemical compounds | SMITHLINE BEECHAM CORPORATION | 2005-12-29 | — | — | US | claimed |
| US-20070142437-A1 | CHEMICAL COMPOUNDS | BROWN MATTHEW L | 2007-06-21 | — | — | US | disclosed |
| US-20070142437-A1 | CHEMICAL COMPOUNDS | BROWN MATTHEW L | 2007-06-21 | — | — | US | disclosed |
| US-7189712-B2 | 1,3-Oxazole compounds for the treatment of cancer | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189712-B2 | 1,3-Oxazole compounds for the treatment of cancer | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-13 | — | — | US | disclosed |
| US-20050288515-A1 | Chemical compounds | SMITHLINE BEECHAM CORPORATION | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142437-A1 | CHEMICAL COMPOUNDS | CDK4, CDK2, CDK3 | VCP 3873/4885KDR 33/4885FLT1 56/4885 |
| US-20050288515-A1 | Chemical compounds | CDK4, CDK2, CDK3 | VCP 3873/4885KDR 33/4885FLT1 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.