Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5462473 | 0.99 | CYP2D6 (0.44) | CYP2D6HTR1AHTR7ADRB2ADRB1 | |
| SCHEMBL5462556 | 0.89 | ADRA1D (0.39) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL5462666 | 0.89 | GRIN2B (0.45) | CYP2D6ADRB2ADRB1ADRB3ADRA1D | |
| SCHEMBL5468867 | 0.88 | ADRA1D (0.38) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL5468377 | 0.87 | ADRA1D (0.39) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL5463829 | 0.86 | GRIN2B (0.44) | CYP2D6KCNH2GRIN2B | |
| SCHEMBL5463189 | 0.84 | TACR2 (0.41) | HTR1AHTR7CCR1GRIN2B | |
| SCHEMBL5466900 | 0.84 | GRIN2B (0.41) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL5468783 | 0.83 | GRIN2B (0.41) | CYP2D6KCNH2DRD2DRD3LMNA | |
| SCHEMBL5464081 | 0.81 | CYP2D6 (0.49) | CYP2D6HTR1AHTR7KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021414-A1 | 1-'2-(4-Hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists | PFIZER, INC. | 2007-01-25 | — | — | US | disclosed |
| EP-1673366-A1 | 1-\"2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL]-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS | Pfizer, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005035522-A1 | 1-‘2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL!-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS | PFIZER JAPAN, INC. (JP) | 2005-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021414-A1 | 1-'2-(4-Hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists | GRIN1, GRIN3A, GRIN2C | CYP2D6 1081/4885HTR1A 271/4885HTR7 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.