Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5457440 | 0.89 | KCNH2 (0.41) | GRIN2BKCNJ1KCNH2CYP2D6ALDH1A1 | |
| SCHEMBL5470384 | 0.86 | GRIN2B (0.39) | GRIN2BKCNJ1KCNH2ALDH1A1LMNA | |
| SCHEMBL5463829 | 0.84 | GRIN2B (0.44) | GRIN2BKCNH2CYP2D6 | |
| SCHEMBL5468477 | 0.83 | CYP2D6 (0.45) | GRIN2BKCNJ1KCNH2CYP2D6LMNA | |
| Hydrochloric Acid SCHEMBL5462473 | 0.82 | CYP2D6 (0.44) | KCNJ1KCNH2CYP2D6LMNACCR1 | |
| SCHEMBL5460592 | 0.82 | KCNJ1 (0.41) | KCNJ1KCNH2CYP2D6ALDH1A1LMNA | |
| SCHEMBL5465846 | 0.81 | KCNH2 (0.39) | KCNJ1KCNH2ALDH1A1LMNADRD2 | |
| Hydrochloric Acid SCHEMBL5462631 | 0.80 | KCNH2 (0.38) | KCNJ1KCNH2ALDH1A1LMNADRD2 | |
| SCHEMBL5476791 | 0.79 | KCNH2 (0.39) | GRIN2BKCNJ1KCNH2CYP2D6ALDH1A1 | |
| SCHEMBL5462556 | 0.78 | ADRA1D (0.39) | GRIN2BKCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021414-A1 | 1-'2-(4-Hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists | PFIZER, INC. | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021414-A1 | 1-'2-(4-Hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists | GRIN1, GRIN3A, GRIN2C | GRIN2B 7/4885KCNJ1 298/4885KCNH2 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.