Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARD | Q03181 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL909943 | 0.90 | ALDH1A1 (0.78) | TDP1ALDH1A1CA2TSHRCYP3A4 | |
| SCHEMBL14015319 | 0.88 | ALDH1A1 (0.56) | TDP1ALDH1A1TSHRAKR1B1GPR84 | |
| Carbamic Acid SCHEMBL28700287 | 0.88 | ALDH1A1 (0.75) | TDP1ALDH1A1CA2TSHRCYP3A4 | |
| Acetic Acid SCHEMBL1878883 | 0.88 | ALDH1A1 (0.75) | TDP1ALDH1A1CA2TSHRCYP3A4 | |
| SCHEMBL29110569 | 0.85 | ALDH1A1 (0.55) | TDP1ALDH1A1TSHRGPR84PPARG | |
| SCHEMBL17062935 | 0.85 | ALDH1A1 (0.55) | TDP1ALDH1A1TSHRGPR84PPARG | |
| Acetoacetic Acid SCHEMBL11587585 | 0.84 | ALDH1A1 (0.62) | TDP1ALDH1A1CA2TSHRCYP3A4 | |
| SCHEMBL21483717 | 0.84 | GABRP (0.48) | TDP1ALDH1A1CA2TSHRMEN1 | |
| SCHEMBL9004577 | 0.83 | ALDH1A1 (1.00) | TDP1ALDH1A1CA2TSHRCYP3A4 | |
| SCHEMBL28690 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070055038-A1 | Adducts containing isocyanate groups and composition adhering effectively to painted substrates | SIKA TECHNOLOGY AG (CH) | 2007-03-08 | — | — | US | claimed |
| US-20070055038-A1 | Adducts containing isocyanate groups and composition adhering effectively to painted substrates | SIKA TECHNOLOGY AG (CH) | 2007-03-08 | — | — | US | disclosed |