Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.48 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22480929 | 0.90 | MRGPRX4 (0.68) | MRGPRX4HPGDMEN1NPC1RAB9A | |
| SCHEMBL22480554 | 0.85 | MRGPRX4 (1.00) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22469778 | 0.83 | MRGPRX4 (0.76) | MRGPRX4SLC6A4HTR6PDCD1CD274 | |
| SCHEMBL31568445 | 0.83 | MRGPRX4 (0.76) | MRGPRX4SLC6A4HTR6PDCD1CD274 | |
| SCHEMBL14854689 | 0.83 | MRGPRX4 (0.76) | MRGPRX4SLC6A4HTR6PDCD1CD274 | |
| SCHEMBL28102426 | 0.83 | MRGPRX4 (0.67) | MRGPRX4SLC6A4HTR6PDCD1CD274 | |
| SCHEMBL22469722 | 0.80 | MRGPRX4 (1.00) | MRGPRX4 | |
| SCHEMBL31568423 | 0.80 | MRGPRX4 (1.00) | MRGPRX4 | |
| SCHEMBL9975339 | 0.80 | MRGPRX4 (0.70) | MRGPRX4SLC6A4HTR6MAPTPDCD1 | |
| SCHEMBL3949409 | 0.80 | MRGPRX4 (0.50) | MRGPRX4HPGDMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | WYETH | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K6 | MRGPRX4 589/4885HPGD 2446/4885MEN1 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.