Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.50 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950320 | 0.80 | FFAR1 (0.45) | MRGPRX4FFAR1FFAR4VNN1CNR1 | |
| SCHEMBL5469717 | 0.80 | MRGPRX4 (0.74) | MRGPRX4RAB9AMEN1NPC1HPGD | |
| SCHEMBL4203997 | 0.77 | SMN1; SMN2 (0.49) | RAB9AMEN1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL20954353 | 0.75 | FFAR1 (0.49) | MRGPRX4SGMS2FFAR1FFAR4VNN1 | |
| SCHEMBL3943298 | 0.74 | FFAR1 (0.43) | MRGPRX4HPGDSGMS2FFAR1FFAR4 | |
| SCHEMBL3951977 | 0.72 | FFAR1 (0.46) | KMT2ASGMS2FFAR1FFAR4CNR1 | |
| SCHEMBL16150588 | 0.71 | ALDH1A1 (0.56) | MRGPRX4FFAR1FFAR4CNR1 | |
| SCHEMBL29248542 | 0.71 | FFAR1 (0.64) | MEN1KMT2AFFAR1FFAR4CNR1 | |
| SCHEMBL22480929 | 0.71 | MRGPRX4 (0.68) | MRGPRX4RAB9AMEN1NPC1HPGD | |
| SCHEMBL3947205 | 0.70 | FFAR1 (0.58) | RAB9AMEN1NPC1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |