Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758033 | 1.00 | OPRK1 (0.46) | OPRK1KCNH2OPRM1KDM4ESLC6A2 | |
| SCHEMBL4757061 | 0.97 | OPRK1 (0.44) | OPRK1KCNH2OPRM1KDM4ESLC6A2 | |
| SCHEMBL20958345 | 0.89 | SLC6A2 (0.50) | OPRK1KCNH2SLC6A2SLC6A3 | |
| SCHEMBL20958343 | 0.89 | SLC6A2 (0.50) | OPRK1KCNH2SLC6A2SLC6A3 | |
| SCHEMBL20958347 | 0.89 | SLC6A2 (0.50) | OPRK1KCNH2SLC6A2SLC6A3 | |
| SCHEMBL547046 | 0.84 | CHRM2 (0.50) | OPRK1KCNH2OPRM1KDM4E | |
| SCHEMBL547045 | 0.84 | CHRM2 (0.50) | OPRK1KCNH2OPRM1KDM4E | |
| Fumaric Acid SCHEMBL1178273 | 0.82 | OPRK1 (0.52) | OPRK1KCNH2OPRM1SLC6A2SLC6A3 | |
| SCHEMBL547468 | 0.82 | CHRM2 (0.48) | OPRK1KCNH2OPRM1KDM4E | |
| SCHEMBL1178215 | 0.81 | SLC6A2 (0.59) | OPRK1KCNH2OPRM1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948653-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NeuroSearch A/S (DK) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054531-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2007-05-18 | — | — | WO | disclosed |