Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184428 | 0.86 | DPP4 (0.50) | DPP4ALDH1A1KMT2AHSD17B10NPSR1 | |
| SCHEMBL5471011 | 0.85 | ALDH1A1 (0.69) | DPP4ALDH1A1KMT2AGAAHSD17B10 | |
| SCHEMBL555383 | 0.80 | DPP4 (0.61) | DPP4ALDH1A1KMT2AGAAHSD17B10 | |
| SCHEMBL28047362 | 0.79 | DPP4 (0.59) | DPP4ALDH1A1KMT2AGAAHSD17B10 | |
| SCHEMBL1242754 | 0.78 | ALDH1A1 (0.60) | DPP4ALDH1A1KMT2AHTTL3MBTL1 | |
| SCHEMBL25236281 | 0.78 | POLB (0.70) | ALDH1A1KMT2AHTTMEN1TSHR | |
| SCHEMBL28047331 | 0.76 | KMT2A (0.65) | DPP4ALDH1A1KMT2AHSD17B10HTT | |
| SCHEMBL5463182 | 0.76 | ALDH1A1 (0.57) | DPP4ALDH1A1GAAHSD17B10HTT | |
| SCHEMBL5465163 | 0.76 | MAOB (0.54) | ALDH1A1KMT2AGAAHSD17B10HPGD | |
| SCHEMBL5182066 | 0.75 | MAPK1 (0.55) | ALDH1A1KMT2AGAAHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236810-B2 | Substituted 8-aminoalkylthioxanthines, and their use as inhibitors of dipeptidyl peptidase IV | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2012-08-07 | — | — | US | disclosed |
| US-20070265284-A1 | SUBSTITUTED 8-AMINOALKYLTHIOXANTHINES, AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265284-A1 | SUBSTITUTED 8-AMINOALKYLTHIOXANTHINES, AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | DPP4, DPP8, DPP7 | DPP4 1/4885ALDH1A1 673/4885KMT2A 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.