Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.88 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.83 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.83 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.83 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.72 |
| ▸ | CDK8 | P49336 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3533699 | 0.99 | MAPK14 (0.86) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL13741201 | 0.94 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3533400 | 0.92 | MAPK14 (0.95) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL13234634 | 0.89 | MAPK14 (0.91) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL2951313 | 0.89 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL12245421 | 0.88 | MAPK14 (0.88) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL18324914 | 0.88 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL1504498 | 0.88 | MAPK14 (0.79) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL13234636 | 0.86 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL13499153 | 0.85 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2924039-A1 | 2-Amino-1-phenyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide derivates | Universität Zürich (CH) | 2015-09-30 | — | — | EP | disclosed |
| US-7662827-B2 | Pyrazole derivatives having tyrosine kinase inhibitory activity | MERCK PATENT GMBH (DE) | 2010-02-16 | — | — | US | disclosed |
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| US-20070010529-A1 | Nitrogenous heterocyclic compounds and medical use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010529-A1 | Nitrogenous heterocyclic compounds and medical use thereof | MAPK1, NOS1, NOS2 | MAPK14 12/4885MAPK13 5/4885MAPK12 13/4885 |
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | TIE1, FER, ROS1 | MAPK14 592/4885MAPK13 654/4885MAPK12 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.