Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5472850 | 0.91 | CCNB2 (0.53) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL5468090 | 0.87 | CCNB2 (0.52) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL5479505 | 0.87 | CCNB2 (0.55) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL5486053 | 0.84 | CCNB2 (0.52) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL5472887 | 0.83 | CCNB2 (0.52) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL14431704 | 0.81 | CCNB2 (0.49) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL5485030 | 0.81 | MAPT (0.52) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL5477004 | 0.79 | CCNB2 (0.48) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL23436466 | 0.74 | XDH (0.53) | MAPTSRCHPGDXDH | |
| SCHEMBL31061395 | 0.71 | EGFR (0.59) | CCNB2CDK1CCNB1CCNB3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197559-A1 | Aryl substituted purine analogues | NEUROGEN CORPORATION | 2007-08-23 | — | — | US | disclosed |
| US-20070197559-A1 | Aryl substituted purine analogues | NEUROGEN CORPORATION | 2007-08-23 | — | — | US | disclosed |
| US-20070197559-A1 | Aryl substituted purine analogues | NEUROGEN CORPORATION | 2007-08-23 | — | — | US | disclosed |
| EP-1720877-A2 | ARYL SUBSTITUTED PURINE ANALOGUES | Neurogen Corporation (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005084401-A2 | ARYL SUBSTITUTED PURINE ANALOGUES | NEUROGEN CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197559-A1 | Aryl substituted purine analogues | ADORA2A, GART, P2RX7 | CCNB2 4127/4885CDK1 3769/4885CCNB1 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.