Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.49 |
| ▸ | AKT1 | P31749 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CDK7 | P50613 | 4/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5478945 | 0.93 | FGFR2 (0.51) | FGFR1FGFR2FGFR3AKT1ROCK1 | |
| SCHEMBL5467086 | 0.92 | FGFR1 (0.52) | FGFR1FGFR2FGFR3AKT1ROCK1 | |
| SCHEMBL5467170 | 0.91 | AKT1 (0.48) | FGFR1FGFR2FGFR3AKT1CDK2 | |
| SCHEMBL4659759 | 0.85 | CDK7 (0.57) | FGFR1FGFR2FGFR3AKT1ROCK1 | |
| SCHEMBL4722252 | 0.82 | AKT1 (0.54) | FGFR1FGFR2FGFR3AKT1ROCK1 | |
| SCHEMBL4722256 | 0.82 | AKT1 (0.54) | FGFR1FGFR2FGFR3AKT1ROCK1 | |
| SCHEMBL18271260 | 0.80 | FGFR2 (0.74) | FGFR1FGFR2FGFR3CDK2ABL1 | |
| SCHEMBL4660760 | 0.78 | AKT1 (0.56) | AKT1ROCK1CDK2CDK7WNT1 | |
| SCHEMBL4659680 | 0.77 | CDK2 (0.54) | FGFR1FGFR2FGFR3AKT1ROCK1 | |
| SCHEMBL4658449 | 0.77 | CDK2 (0.52) | FGFR1AKT1ROCK1CDK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185152-A1 | Inhibitors of akt activity | SMITHKLINE BEECHAM CORPORATION | 2007-08-09 | — | — | US | claimed |
| US-20070185152-A1 | Inhibitors of akt activity | SMITHKLINE BEECHAM CORPORATION | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185152-A1 | Inhibitors of akt activity | AKT1, AKT1S1, AKT2 | FGFR1 1565/4885FGFR2 1337/4885FGFR3 1449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.