Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.84 |
| ▸ | PDE5A | O76074 | 10/20 | 0.56 |
| ▸ | GUCY1A1 | Q02108 | 8/20 | 0.52 |
| ▸ | GUCY1B1 | Q02153 | 8/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Riociguat SCHEMBL29357210 | 0.92 | KCNH2 (1.00) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| Riociguat SCHEMBL29419573 | 0.92 | KCNH2 (1.00) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| Riociguat SCHEMBL245457 | 0.92 | KCNH2 (1.00) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| Riociguat SCHEMBL29379983 | 0.92 | KCNH2 (1.00) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL12593410 | 0.91 | KCNH2 (0.86) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL5484675 | 0.90 | ADORA3 (0.68) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL31037565 | 0.89 | KCNH2 (0.83) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL5478659 | 0.89 | KCNH2 (0.83) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL30507540 | 0.89 | ADORA3 (0.82) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL174915 | 0.89 | ADORA3 (0.82) | KCNH2ADORA3PDE5AGUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492544-B2 | Process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-B]pyridin-3-yl]pyrimidin-5-yl}Methylcarbamate and its purification for use as pharmaceutically active compound | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20070225299-A1 | Novel Combination Containing a Stimulator of Soluble Guanylate Cyclase and a Lipid-Lowering Substance | BAYER HEALTHCARE AG (DE) | 2007-09-27 | — | — | US | disclosed |
| US-20070225299-A1 | Novel Combination Containing a Stimulator of Soluble Guanylate Cyclase and a Lipid-Lowering Substance | BAYER HEALTHCARE AG (DE) | 2007-09-27 | — | — | US | disclosed |
| US-20070225299-A1 | Novel Combination Containing a Stimulator of Soluble Guanylate Cyclase and a Lipid-Lowering Substance | BAYER HEALTHCARE AG (DE) | 2007-09-27 | — | — | US | disclosed |
| US-7173037-B2 | Carbamate-substituted pyrazolopyridines | BAYER HEALTHCARE AG (DE) | 2007-02-06 | — | — | US | disclosed |
| US-7173037-B2 | Carbamate-substituted pyrazolopyridines | BAYER HEALTHCARE AG (DE) | 2007-02-06 | — | — | US | disclosed |
| US-7173037-B2 | Carbamate-substituted pyrazolopyridines | BAYER HEALTHCARE AG (DE) | 2007-02-06 | — | — | US | disclosed |
| US-20060052397-A1 | Compounds for trearment of cardiovascular disorders and hypotensive agents | BAYER HEALTHCARE AG (DE) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225299-A1 | Novel Combination Containing a Stimulator of Soluble Guanylate Cyclase and a Lipid-Lowering Substance | GUCY1A2, GUCY1B2, GUCY1B1 | KCNH2 2335/4885ADORA3 928/4885PDE5A 9/4885 |
| US-20060052397-A1 | Compounds for trearment of cardiovascular disorders and hypotensive agents | PDE3A, PDE3B, PDE2A | KCNH2 917/4885ADORA3 221/4885PDE5A 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.