⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14270060 | 0.86 | DPP4 (0.40) | — | |
| SCHEMBL5482843 | 0.86 | DPP4 (0.40) | — | |
| SCHEMBL18773606 | 0.84 | EPHX2 (0.33) | — | |
| SCHEMBL29700 | 0.84 | — | — | |
| SCHEMBL9393516 | 0.84 | EPHX2 (0.33) | — | |
| SCHEMBL4456910 | 0.84 | EPHX2 (0.33) | — | |
| SCHEMBL2369691 | 0.84 | — | — | |
| SCHEMBL2369685 | 0.84 | — | — | |
| SCHEMBL12571497 | 0.84 | — | — | |
| SCHEMBL10042827 | 0.83 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669255-B2 | Pyrrole derivatives | HUA MEDICINE (SHANGHAI) LTD. (CN) | 2020-06-02 | — | — | US | disclosed |
| US-20190100506-A1 | Pyrrole Derivatives | HUA MEDICINE (SHANGHAI) LTD. (CN) | 2019-04-04 | — | — | US | disclosed |
| US-9540387-B2 | Substituted imidazo[1,2-d]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2017-01-10 | — | — | US | disclosed |
| US-9540387-B2 | Substituted imidazo[1,2-d]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2017-01-10 | — | — | US | disclosed |
| US-20160046642-A1 | Compounds for Treating Respiratory Syncytial Virus Infections | BIOTA SCIENT MANAGEMENT (AU) | 2016-02-18 | — | — | US | disclosed |
| US-20160046642-A1 | Compounds for Treating Respiratory Syncytial Virus Infections | BIOTA SCIENT MANAGEMENT (AU) | 2016-02-18 | — | — | US | disclosed |
| US-7964613-B2 | (S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine; inhibits phosphorylation of myosin regulatory light chain; for spinal canal stenosis, spinal cord injury, rheumatoid arthritis, multiple sclerosis; Rho kinase inhibitors | ASAHI KASEI PHARMA CORPORATION (JP) | 2011-06-21 | — | — | US | disclosed |
| US-7964613-B2 | (S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine; inhibits phosphorylation of myosin regulatory light chain; for spinal canal stenosis, spinal cord injury, rheumatoid arthritis, multiple sclerosis; Rho kinase inhibitors | ASAHI KASEI PHARMA CORPORATION (JP) | 2011-06-21 | — | — | US | disclosed |
| US-20090048223-A1 | Sulfonamide compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-02-19 | — | — | US | disclosed |
| US-20090048223-A1 | Sulfonamide compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-02-19 | — | — | US | disclosed |
| US-20070255064-A1 | Imidazolium-Methyl Sulfites for Use as Starting Compounds for Producing Ionic Liquids | BASF AKTIENGESELLSCHAFT (DE) | 2007-11-01 | — | — | US | disclosed |