Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | AGXT | P21549 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11991410 | 0.83 | TAAR1 (0.62) | TAAR1CHRM2CHRM1CHRM3SIGMAR1 | |
| SCHEMBL6943329 | 0.82 | CYP4F2 (0.61) | ABCB1HTR1ADRD2CYP2D6 | |
| SCHEMBL10257696 | 0.82 | ACACB (0.40) | TAAR1MTNR1AMTNR1BCYP2D6 | |
| SCHEMBL10235916 | 0.82 | CYP2D6 (0.49) | CYP2D6 | |
| SCHEMBL611119 | 0.81 | TAAR1 (0.45) | TAAR1CYP2D6 | |
| SCHEMBL14979585 | 0.81 | TAAR1 (0.42) | TAAR1AOC3MTNR1AMTNR1B | |
| SCHEMBL267087 | 0.80 | TAAR1 (0.72) | TAAR1CHRM2CHRM1CHRM3SIGMAR1 | |
| SCHEMBL7604631 | 0.80 | HTT (0.56) | TAAR1 | |
| SCHEMBL21002046 | 0.79 | AOC3 (0.57) | TAAR1CHRM2CHRM1CHRM3SIGMAR1 | |
| SCHEMBL723511 | 0.78 | TAAR1 (0.77) | TAAR1CHRM2CHRM1CHRM3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210046009-A1 | PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS | Grünenthal GmbH (DE) | 2021-02-18 | — | — | US | disclosed |
| US-20200276188-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2020-09-03 | — | — | US | disclosed |
| US-20200268748-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | GRUNENTHAL GMBH (DE) | 2020-08-27 | — | — | US | disclosed |
| EP-3698776-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2020-08-26 | — | — | EP | disclosed |
| US-10675278-B2 | Crush resistant delayed-release dosage forms | Grünenthal GmbH (DE) | 2020-06-09 | — | — | US | disclosed |
| US-10624862-B2 | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer | Grünenthal GmbH (DE) | 2020-04-21 | — | — | US | disclosed |
| CN-105682643-B | Tamper resistant dosage form containing ethylene-vinyl acetate polymer | 格吕伦塔尔有限公司 | 2019-12-13 | — | — | CN | disclosed |
| US-20190111050-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2019-04-18 | — | — | US | disclosed |
| US-20190054081-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2019-02-21 | — | — | US | disclosed |
| US-20180369235-A1 | CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS | Grünenthal GmbH (DE) | 2018-12-27 | — | — | US | disclosed |
| US-9737490-B2 | Tamper resistant dosage form with bimodal release profile | Grünenthal GmbH (DE) | 2017-08-22 | — | — | US | disclosed |
| US-20170112766-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2017-04-27 | — | — | US | disclosed |
| US-20160310487-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | GRUNENTHAL GMBH (DE) | 2016-10-27 | — | — | US | disclosed |
| US-20160310429-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2016-10-27 | — | — | US | disclosed |
| US-20160184297-A1 | CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS | Grünenthal GmbH (DE) | 2016-06-30 | — | — | US | disclosed |
| US-20150164807-A1 | TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE MANUFACTURED BY CO-EXTRUSION | Grünenthal GmbH (DE) | 2015-06-18 | — | — | US | disclosed |
| US-20140356428-A1 | TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE | Grünenthal GmbH (DE) | 2014-12-04 | — | — | US | disclosed |
| US-20140112984-A1 | Crush resistant delayed-release dosage forms | GRUENENTHAL GMBH (DE) | 2014-04-24 | — | — | US | disclosed |
| WO-2013111161-A2 | PROCESS FOR THE PREPARATION OF 3-ARYL-2-METHYL-PROPANAMINE DERIVATIVES AND POLYMORPHS THEREOF | MSN LABORATORIES LIMITED (IN) | 2013-08-01 | — | — | WO | disclosed |
| US-20070298091-A1 | Transdermal Therapeutic System For Administering Analgesics | GRUENENTHAL GMBH (DE) | 2007-12-27 | — | — | US | disclosed |