Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.33 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23493163 | 0.89 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19MAPTPKM | |
| SCHEMBL229622 | 0.74 | MAPT (0.62) | CYP1A2CYP2C9CYP2C19MAPTPKM | |
| SCHEMBL3519630 | 0.74 | MAPT (0.62) | MAPTPKMMAPK1ALDH1A1MEN1 | |
| SCHEMBL8758907 | 0.73 | TXNRD1 (0.30) | ALDH1A1CYP3A4TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL9452645 | 0.73 | ALDH1A1 (0.52) | CYP1A2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL6989713 | 0.72 | CYP1A2 (0.47) | CYP1A2CYP2C9CYP2C19MAPTMAPK1 | |
| SCHEMBL3179870 | 0.71 | ALDH1A1 (0.50) | CYP1A2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL15826052 | 0.69 | MAPT (0.48) | CYP1A2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL10431416 | 0.69 | CYP1A2 (0.45) | CYP1A2CYP2C9CYP2C19MAPTPKM | |
| SCHEMBL30849385 | 0.69 | ALDH1A1 (0.43) | MAPTMAPK1ALDH1A1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066671-A1 | Substituted benzimidazoles, production and use thereof as agents for combating parasitic protozoas | BAYER AKTIENGESELLSCHAFT (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066671-A1 | Substituted benzimidazoles, production and use thereof as agents for combating parasitic protozoas | BAYER AKTIENGESELLSCHAFT (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066671-A1 | Substituted benzimidazoles, production and use thereof as agents for combating parasitic protozoas | BAYER AKTIENGESELLSCHAFT (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20040010025-A1 | Substituted benzimidazoles, their preparation and their use as agents against parasitic protozoa | GREIF GISELA (DE) | 2004-01-15 | — | — | US | disclosed |
| EP-1177191-B1 | SUBSTITUTED BENZIMIDAZOLE, THE PRODUCTION THEREOF AND THE USE THEREOF AS MEANS AGAINST PARASITIC PROTOZOA | BAYER AG (DE) | 2003-12-10 | — | — | EP | disclosed |
| EP-1097154-B1 | SUBSTITUTED BENZIMIDAZOLES, PRODUCTION AND USE THEREOF AS AGENTS FOR COMBATING PARASITIC PROTOZOAS | BAYER AG (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6620833-B1 | Coccidiosis treatment; 4,5-tetrafluoroethylenedioxybenzimidazole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2003-09-16 | — | — | US | disclosed |
| US-6569881-B1 | For mixture with polyether antibiotics or synthetically prepared coccidiosis agents | BAYER AKTIENGESELLSCHAFT (DE) | 2003-05-27 | — | — | US | disclosed |
| WO-2003002115-A2 | SUBSTITUTED BENZIMIDAZOLES FOR CONTROLLING ENDOPARASITES | BAYER AKTIENGESELLSCHAFT (DE) | 2003-01-09 | — | — | WO | disclosed |
| EP-1177191-A1 | SUBSTITUTED BENZIMIDAZOLE, THE PRODUCTION THEREOF AND THE USE THEREOF AS MEANS AGAINST PARASITIC PROTOZOA | Bayer Aktiengesellschaft (DE) | 2002-02-06 | — | — | EP | disclosed |
| EP-1097154-A1 | SUBSTITUTED BENZIMIDAZOLES, PRODUCTION AND USE THEREOF AS AGENTS FOR COMBATING PARASITIC PROTOZOAS | Bayer Aktiengesellschaft (DE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000068225-A1 | SUBSTITUTED BENZIMIDAZOLE, THE PRODUCTION THEREOF AND THE USE THEREOF AS MEANS AGAINST PARASITIC PROTOZOA | BAYER AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |
| WO-2000004022-A1 | SUBSTITUTED BENZIMIDAZOLES, PRODUCTION AND USE THEREOF AS AGENTS FOR COMBATING PARASITIC PROTOZOAS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040010025-A1 | Substituted benzimidazoles, their preparation and their use as agents against parasitic protozoa | CYP2E1, CBR1, BAK1 | CYP1A2 41/4885CYP2C9 169/4885CYP2C19 109/4885 |
| US-20070066671-A1 | Substituted benzimidazoles, production and use thereof as agents for combating parasitic protozoas | CBR1, CBR3, H1-3 | CYP1A2 51/4885CYP2C9 251/4885CYP2C19 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.