Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13726900 | 0.86 | POLB (0.55) | POLBPRMT1CYP19A1PKMHTR6 | |
| SCHEMBL5470742 | 0.84 | POLB (0.52) | POLBPRMT1CYP19A1PKMHTR6 | |
| SCHEMBL17978501 | 0.79 | POLB (0.62) | POLBPKMHTR6F2PRSS1 | |
| SCHEMBL9329231 | 0.78 | PTGES2 (0.51) | POLBSLC16A3ALDH1A1PTGES2TSHR | |
| SCHEMBL5472507 | 0.76 | POLB (0.62) | POLBPKMHTR6ALDH1A1TSHR | |
| SCHEMBL17779177 | 0.76 | TSHR (0.63) | POLBPKMHTR6ALDH1A1PTGES2 | |
| SCHEMBL5480533 | 0.76 | POLB (0.62) | POLBPKMHTR6ALDH1A1SMN1; SMN2 | |
| SCHEMBL5470332 | 0.75 | ALDH1A1 (0.60) | POLBPKMHTR6F2PRSS1 | |
| SCHEMBL1956403 | 0.75 | MEN1 (0.66) | POLBPKMHTR6ALDH1A1HSD17B10 | |
| SCHEMBL17978457 | 0.75 | KMT2A (0.59) | POLBPKMHTR6ALDH1A1PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | NR5A1, GNRHR, RXFP3 | POLB 3320/4885PRMT1 898/4885CYP19A1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.