Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704100 | 0.79 | POLB (0.75) | POLBNPC1TDP1GRIN2BHPGD | |
| SCHEMBL5487171 | 0.76 | CYP4F2 (0.50) | KDM1ACYP4F2CYP4A11 | |
| SCHEMBL3421589 | 0.72 | CYP4F2 (0.47) | KDM1ACYP4F2CYP4A11 | |
| SCHEMBL12945058 | 0.71 | POLB (0.67) | POLBNPC1TDP1GRIN2BHPGD | |
| SCHEMBL17117487 | 0.70 | POLB (0.61) | POLBNPC1TDP1FKBP1ANAAA | |
| SCHEMBL14028152 | 0.69 | POLB (0.73) | POLBNPC1TDP1GRIN2BHPGD | |
| SCHEMBL1221986 | 0.69 | POLB (1.00) | POLBNPC1TDP1GRIN2BHPGD | |
| SCHEMBL4775094 | 0.69 | NCF1 (0.53) | NPC1HPGDSMN1; SMN2KDM1ACYP4F2 | |
| SCHEMBL6289171 | 0.69 | POLB (0.77) | POLBNPC1TDP1GRIN2BHPGD | |
| SCHEMBL30967880 | 0.69 | FFAR1 (0.51) | KDM1ACYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007516982-A | — | — | 2007-06-28 | — | — | JP | claimed |
| EP-1694410-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2006-08-30 | — | — | EP | claimed |
| WO-2005058884-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-06-30 | — | — | WO | claimed |