SCHEMBL5478651

SCHEMBL5478651

Cc1oc(-c2ccccc2)nc1CNCc1nccs1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 8/20 0.48
POLB P06746 1/20 0.48
TSHR P16473 1/20 0.48
MAPK1 P28482 1/20 0.48
RAB9A P51151 1/20 0.48
KDM4E B2RXH2 1/20 0.47
PPARG P37231 8/20 0.47
LMNA P02545 2/20 0.46
MAPT P10636 2/20 0.43
TP53 P04637 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
HPGD P15428 1/20 0.42
KDR P35968 1/20 0.41
PPARD Q03181 1/20 0.40
FFAR1 O14842 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10447399 0.77 KDM4E (0.57) PPARARAB9AKDM4EPPARGLMNA
SCHEMBL5480570 0.77 PPARA (0.52) PPARAKDM4EPPARGLMNAMAPT
SCHEMBL9316924 0.74 KDM4E (0.60) PPARARAB9AKDM4EPPARGLMNA
SCHEMBL3761024 0.72 KDM4E (0.58) PPARARAB9AKDM4EPPARGLMNA
SCHEMBL5478649 0.72 KDM4E (0.46) PPARAPOLBTSHRMAPK1RAB9A
SCHEMBL7992107 0.71 KDM1A (0.50) KDM4ETP53
SCHEMBL2979513 0.70 HRH3 (0.59) PPARARAB9AKDM4EPPARGLMNA
SCHEMBL6383756 0.70 KDM4E (0.63) PPARAMAPK1RAB9AKDM4EPPARG
SCHEMBL2311217 0.70 CYP2C19 (0.46) TSHR
SCHEMBL266619 0.69 KDM4E (0.66) PPARARAB9AKDM4EPPARGLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
EP-1731513-A1 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD PPARA 1/4885POLB 1509/4885TSHR 176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.